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The proton pump inhibitors have been used for over 30 years and have an excellent safety profile. Some people may experience problems with headaches, skin rash, diarrhea, and abnormal liver function studies but these side effects are extremely rare. Recently, there has been some suggestion that older individuals on long-term high dose, that is twice a day, proton pump inhibitors may have an increased bone fracture rate and, therefore, should be taking a calcium and vitamin D supplement. However this has not been substantiated.
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Important: This information should not be used as a substitute for the medical care and advice of your physician.